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Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

The series focuses on the romantic tension between the oblivious military-minded Sousuke Sagara and the beautiful Kaname Chidori. Set in their school Jindai High, the couple is up for various crazy and hilarious misunderstandings, often caused by Sousuke’s ignorance.

Mitsuki Hayase's best friend, Haruka Suzumiya, has a crush on Takayuki Narumi. Mitsuki originally only becomes friends with Takayuki because of Haruka's crush, but after Haruka confesses her feelings the two others begin to realize their feelings for each other.

Kagome Higurashi, a normal 15-year-old girl, falls down a dry well--and finds herself in the feudal past, 50 years after her ancestress Kikyo imprisoned the half-human/half-demon Inu-Yasha. As the reincarnation of Kikyo, Kagome possesses a magic jewel that greatly increases the power of demons.

Failure Human Tsukune is unexpectedly put into a school for monsters, where he meets the cute vampire Moka. He later meets succubus, Kurumu, a young witch genius, Yukari, an ice girl, Mizore, and Ruby a second older Witch Adept, Ruby.