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The "Seven Deadly Sins," a group of evil knights who conspired to overthrow the kingdom of Britannia, were said to have been eradicated by the Holy Knights, although some claim that they still live. Ten years later, the Holy Knights have staged a Coup d'état and assassinated the king, becoming the new, tyrannical rulers of the kingdom.

When a great demon fox attacked Hidden Leaf Village, a powerful man known as the 4th Hokage had sealed the demon inside a newborn named Naruto, who then grew up detested by his fellow Leaf villagers. As a child, Naruto is isolated from the Konoha community, who regards him as if he was the Nine-Tails.

Nanami is a homeless high schooler until she accepts an offer to live at a shrine - making her the new local god. With her handsome fox spirit familiar, Nanami learns the ins and outs of godhood and meets more spirits - including two who vie for her love!

Edward Elric makes a fatal mistake that drags his brother and his own body into an abyss, and they must seek the philosopher's stone to return their bodies to normal. They learn more and more about alchemy along the way during their adventures.