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Edward Elric makes a fatal mistake that drags his brother and his own body into an abyss, and they must seek the philosopher's stone to return their bodies to normal. They learn more and more about alchemy along the way during their adventures.

When a great demon fox attacked Hidden Leaf Village, a powerful man known as the 4th Hokage had sealed the demon inside a newborn named Naruto, who then grew up detested by his fellow Leaf villagers. As a child, Naruto is isolated from the Konoha community, who regards him as if he was the Nine-Tails.

Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

Cross Academy is different from any other school. It has a Day Class and a Night Class, with different uniforms and no interaction between these two classes.

Shibusen, standing for Death Weapon Meister Academy (DWMA) the technical school for Reaper Armsmasters that operates from the deepest recesses of all the corners of the world, in order to prevent the second coming of the so-called Demon God who is feared upon bringing destruction of all humankind and envelop the world with nothing but madness and darkness. The reaper built this agency for weapons and for those who will be trained to wield them.